"[D]ecades of perceived humiliation by the West." Thus Roger Cohen characterizes Iran's many complaints against the US (and a handful of other nations, most notably Britain).
Inability to place blame where blame is due when doing so would undermine American jingoist mythology — an essential requirement for any American pundit.
The 1953 overthrow of Mossadegh. Years of of support for the brutal Shah. The 1988 attack on Iran Air Flight 655, killing 290 (after which the Vincennes Capt. Rogers was rewarded). Years of increasingly brutal sanctions whose only substantive impact is on average Iranians. Overflights by American drones. Likely US support for military incursions into Iran (as reported by Seymour Hersh), which are acts of war under the international law the US demands Iran obey. The placement of US forces in nearly every country bordering Iran. The Stuxnet attack concocted by the US and Israel. A constant stream of invective and bigotry from Americans against Iranians and Islam. US support for and training of the MEK and blind eye turned toward express violations by prominent Americans (like Rudolf Giuliani) of US laws against support for terrorism.
And Mr. Cohen's most glaring omission: The slavish obedience of American politicians (and pundits) to Israel's Likudniks, including AIPAC.
What about this is just perceived? What about it would given any Iranian, even the most liberal, any reason to trust the US?
The real question is what humiliations remain unperceived, still secret.